骨质疏松症中铁死亡的分子机制

Molecular mechanism of ferroptosis in osteoporosis

骨质疏松症是老年人的一种常见病,其主要特征为骨强度降低、骨密度减少及骨折风险增加。铁死亡是一种新的铁依赖性程序性细胞死亡过程,在调节骨质疏松的发生发展方面至关重要,但其潜在机制较为复杂。本文讨论了铁死亡在骨质疏松症中的分子机制及其相关研究进展,以期为今后关于铁死亡与骨质疏松的研究提供新的参考。

Osteoporosis(OP)is a common disease in the elderly,characterized by decreased bone strength,decreased bone density,and increased risk of fractures.Ferroptosis is a novel iron-dependent programmed cell death process that is critical in regulating the development of osteoporosis,but its underlying mechanism is complex.This article discusses the molecular mechanism of ferroptosis in osteoporosis and related research progress,in order to provide new references for future research on ferroptosis and osteoporosis.