摘要
癌症是复杂的系统性疾病,克服多药耐药性是癌症治疗的主要挑战。网络药理学由于其系统性、整体性的特点与中医整体观念有共通之处,结合中药多成分、多靶点的特性,在中药复方药物、中医病证结合和中药药性理论研究等领域近年来均有进展,在抗肿瘤药物研发领域也受到广泛关注。随着网络药理学技术的发展,通过其进行药物组合设计,充分利用SL大数据,有望发挥中药多靶点作用特点和组方用药模式的优势,实现肿瘤中药/成分“合成致死”配伍组方,提升中医药在肿瘤临床治疗疗效。
Cancer is a complex and systemic disease.Overcoming multidrug resistance is a major challenge in cancer treatment.Network pharmacology has made progress in the fields of traditional Chinese medicine(TCM)compound drugs,TCM disease-syndrome combination and TCM drug property theory research in recent years due to its systematic and holistic characteristics that are similar to those of TCM holistic concept and the characteristics of TCM multi-components and multitargets.It has also attracted extensive attention in the field of antitumor drug research and development.With the development of network pharmacology technology,the drug combination design and the full use of SL big data are expected to give full play to the characteristics of TCM multi-target effects and the advantages of prescription medication mode,realize the“synthetic lethal”compatibility prescription of tumor TCM/components,and improve the clinical efficacy of TCM in tumor treatment.
作者
何俗非
王邈
He Su-fei;Wang Miao(Ministry-Provincial Co-constructed Modern Chinese Medicine Cooperative Innovation Center,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;School of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《科学与信息化》
2023年第21期162-165,共4页
Technology and Information
基金
国家自然科学基金,项目名称:精准肿瘤学理念下抗肿瘤中药“合成致死”配伍组方模式研究,项目编号:82004218
天津市高等学校科技发展基金计划项目,项目名称:从膳食结构诱导的肠道微生态差异探讨痰湿体质的形成机制,项目编号:2017KJ165。
关键词
中医药复方
药性
病证结合
网络药理学
抗肿瘤应用
TCM compound
drug property
combination of disease and syndrome
network pharmacology
antitumor application
