氨甲环酸治疗轻中度颅脑损伤的效果及对其预后的影响

Effect of Tranexamic Acid on Mild and Moderate Craniocerebral Injury and its Influence on Prognosis

目的:探讨氨甲环酸治疗轻中度颅脑损伤的效果及对其预后的影响。方法:选取2019年1月—2022年1月我院收治的82例轻中度颅脑损伤患者作为研究对象,按照随机数字表法分为观察组和对照组,对照组41例予以安慰剂治疗,观察组41例予以氨甲环酸药物治疗,比较两组治疗效果、凝血指标、预后情况以及不良反应。结果:观察组治疗后颅内血肿体积小于对照组,开颅手术率低于对照组,入住NICU时间、住院时间短于对照组(P<0.05);观察组D-D、FIB、FDP水平高于对照组,PT短于对照组(P<0.05);观察组治疗后1、3个月GOS评分均高于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:氨甲环酸治疗轻中度颅脑损伤患者有助于增强治疗效果,改善凝血功能和预后,且无不良反应发生。

Objective:To investigate the effect of tranexamic acid in the treatment of mild to moderate craniocerebral injury and its effect on prognosis.Methods:A total of 82 patients with mild to moderate craniocerebral injury admitted to our hospital from January 2019 to January 2022 were selected as the research objects.According to the random number table method,they were divided into observation group and control group.41 patients in the control group were treated with placebo,and 41 patients in the observation group were treated with tranexamic acid.The therapeutic effect,coagulation index,prognosis and adverse reactions were compared between the two groups.Results:After treatment,the volume of intracranial hematoma in the observation group was smaller than that in the control group,the rate of craniotomy was lower than that in the control group,the time of admission to NICU and the length of hospital stay were shorter than those in the control group(P<0.05).The levels of D-D,FIB and FDP in the observation group were higher than those in the control group,and PT was shorter than that in the control group(P<0.05).GOS score of observation group was higher than that of control group at 1 and 3 months after treatment(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Tranexamic acid in the treatment of patients with mild to moderate craniocerebral injury is helpful to enhance the therapeutic effect,improve coagulation function,improve prognosis,and no adverse events occur.