氯吡格雷与尤瑞克林联合治疗急性脑梗死的疗效研究

Efficacy of Clopidogrel Combined with Urinary Kallidinogenase in the Treatment of Acute Cerebral Infarction

目的:探讨氯吡格雷与尤瑞克林联合治疗急性脑梗死的疗效。方法:选择2021年1月—12月本院诊治的急性脑梗死患者76例作为研究对象,根据1∶1简单分配原则分为尤瑞克林组与对照组,各38例。对照组给予氯吡格雷治疗,尤瑞克林组在对照组治疗基础上给予尤瑞克林治疗,比较两组临床疗效、炎症因子水平[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、脑梗死面积及日常生活能力。结果:尤瑞克林组总有效率为92.1%,高于对照组的71.1%(P<0.05)。治疗后,两组血清TNF-α和IL-6含量低于治疗前,且尤瑞克林组低于对照组(P<0.05);两组脑梗死面积低于治疗前,且尤瑞克林组低于对照组(P<0.05);两组Barthel指数评分高于治疗前,且尤瑞克林组高于对照组(P<0.05)。结论:氯吡格雷与尤瑞克林联合治疗急性脑梗死的疗效确切,可抑制血清TNF-α和IL-6表达,降低脑梗死面积,提高患者日常生活能力。

Objective:To investigate the efficacy of clopidogrel combined with uricrine in the treatment of acute cerebral infarction.Methods:A total of 76 patients with acute cerebral infarction diagnosed and treated in our hospital from January to December 2021 were selected as the research objects.According to the simple distribution principle of 1:1,they were divided into the urinary kallidinogenase group and the control group,with 38 cases in each group.The control group was treated with clopidogrel,and the urinary kallidinogenase group was treated with urinary kallidinogenase on the basis of the control group.The clinical efficacy,inflammatory factor levels[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],cerebral infarction area and daily living ability were compared between the two groups.Results:The total effective rate of the urinary kallidinogenase group was 92.1%,which was higher than 71.1%of the control group(P<0.05).After treatment,the levels of serum TNF-αand IL-6 in the two groups were lower than those before treatment,and those in the urinary kallidinogenase group were lower than the control group(P<0.05);the cerebral infarction area of the two groups was lower than that before treatment,and the urinary kallidinogenase group was lower than the control group(P<0.05);the Barthel index score of the two groups was higher than that before treatment,and that of the urinary kallidinogenase group was higher than that of the control group(P<0.05).Conclusion:Clopidogrel combined with urinary kallidinogenase is effective in the treatment of acute cerebral infarction.It can inhibit the expression of serum TNF-αand IL-6,reduce the area of cerebral infarction and improve the daily living ability of patients.