摘要
胃癌是我国常见的恶性肿瘤之一。胃癌患者中,局部进展期胃癌占比高。对于此类患者,单纯施行手术治疗疗效较差,并且术后复发风险较高。随着治疗模式的不断发展,出现了各类临床试验和新的治疗理念,局部进展期胃癌的治疗模式也由单一化疗逐渐转变为多种疗法联合等新型治疗模式,以改善患者疗效并延长其生存时间。笔者深入阐述局部进展期胃癌围手术期新辅助化疗和转化治疗现状及进展。
Gastric cancer is one of the common malignant tumors in China.Among all gastric cancer patients,locally advanced gastric cancer(LAGC)accounts for a high proportion.For this group of patients,the efficacy of surgery alone is limited,and the risk of postoperative recur-rence is high.With the continuous development of therapy mode,various clinical trials and new treatment concepts have emerged,leading to a shift in treatment approaches of LAGC from the previous single chemotherapy to various combination therapies and other novel treatment moda-lities,with the aim to improve efficacy and extend survival of patients.The authors review the current status and progress of neoadjuvant chemotherapy and conversion therapy for LAGC.
作者
刘凤林
蔡天翼
顾杨阳
Liu Fenglin;Cai Tianyi;Gu Yangyang(Second Department of Gastric Surgery,Fudan University Shanghai Cancer Center,Shanghai 200032,China;Department of General Surgery,Zhongshan Hospital of Fudan University,Shanghai 200032,China;Department of Gastrointestinal Surgery,Nantong Rich Hospital,Nantong 226010,Jiangsu Province,China)
出处
《中华消化外科杂志》
CAS
CSCD
北大核心
2023年第10期1166-1172,共7页
Chinese Journal of Digestive Surgery
基金
国家自然科学基金(82172803,82373381)。
关键词
胃肿瘤
局部进展期
新辅助化疗
转化治疗
进展
Stomach neoplasms
Locally advanced
Neoadjuvant chemotherapy
Con-version therapy
Progress
