基于脾胃气化内涵探讨中医药对肠黏膜屏障的保护作用

Discussion on the protective effect of Traditional Chinese Medicine on intestinal mucosal barrier based on the connotation of gasification of spleen and stomach

肠黏膜屏障受损是肠道疾病的重要发生机制,维护肠黏膜屏障结构完整和功能正常对于许多肠道及肠外疾病的治疗十分关键。同时,脾胃气化失常是各种疾病发生发展的重要基础病机,主要表现在气机升降失司和水谷精微运化输布障碍2个方面的紊乱。研究证实,中医药对肠黏膜屏障有较好的保护作用,其可通过调节脾胃气化功能,多靶点、多途径促进肠黏膜屏障损伤修复及功能恢复,从而起到内源性保护剂的作用。充分认识脾胃气化以肠黏膜屏障为物质基础的内涵,深入探讨中医药对肠黏膜屏障的保护作用机制,对肠道及肠外相关疾病的防治具有重要意义。

Damage to intestinal mucosal barrier is an important pathogenesis of intestinal diseases.Maintaining the structural integrity and normal function of intestinal mucosal barrier is crucial for the treatment of many intestinal and extra-intestinal diseases.At the same time,dysfunctional gasification of spleen and stomach is also an important basic pathogenesis for the occurrence and development of various diseases,mainly manifested as abnormal qi ascending and descending,and the disorder of water and grain essence transportation and transformation.Studies have confirmed that Traditional Chinese Medicine has a good protective effect on intestinal mucosal barrier,which can play the role of endogenous protective agent by regulating the gasification of spleen and stomach,and promoting the repair and functional recovery of intestinal mucosal barrier by multiple targets and various ways.It is of great significance for the prevention and treatment of intestinal and extra-intestinal diseases to fully understand the connotation that intestinal mucosal barrier is the material basis of gasification of spleen and stomach and to deeply explore the mechanism of the protective effect of Traditional Chinese Medicine on the intestinal mucosal barrier.