皮炎消颗粒联合中药湿敷治疗颜面部过敏性皮炎疗效观察

Efficacy of Piyanxiao granule combined with traditional Chinese medicine wet compress in the treatment of facial allergic dermatitis

目的观察皮炎消颗粒联合中药湿敷治疗颜面部过敏性皮炎的临床效果。方法选取2020年6月至2022年6月在延安市中医医院皮肤科接受治疗的116例颜面部过敏性皮炎患者为研究对象,采取随机数表法分为对照组(采取中药湿敷治疗方式)和观察组(采取皮炎消颗粒联合中药湿敷治疗方式)各58例,于治疗1个月后比较两组患者的临床疗效,以及治疗前后的皮肤颜色指数、皮肤发热指数、皮肤瘙痒程度等积分和血清免疫球蛋白E(IgE)水平、嗜酸性粒细胞(EOS)数目变化;同时比较两组患者的不良反应发生情况。结果观察组患者的治疗总有效率为74.14%,明显高于对照组的55.17%,差异有统计学意义(P<0.05);观察组患者的皮肤颜色指数、发热指数及瘙痒程度积分分别为(0.69±0.12)分、(0.72±0.14)分及(0.83±0.23)分,明显低于对照组的(1.03±0.23)分、(1.21±0.32)分及(1.15±0.35)分,差异均有统计学意义(P<0.05);观察组患者的血清总IgE和EOS分别为(109.07±16.45)IU/mL,(2.87±0.12)×10^(9)/mL,明显低于对照组的(116.23±16.43)IU/mL、(3.32±0.23)×10^(9)/mL,差异均具有统计学意义(P<0.05);观察组患者治疗期间的不良反应总发生率为6.90%,略低于对照组的8.62%,但差异无统计学意义(P>0.05)。结论皮炎消颗粒联合中药湿敷治疗颜面部过敏性皮炎不仅可缓解皮肤颜色发红、发热、瘙痒等症状,而且能改善患者的机体炎症水平,临床应用效果好且不良反应少。

Objective To observe the clinical effects of Piyanxiao granule combined with traditional Chinese medicine wet compress in treating facial allergic dermatitis.Methods A total of 116 patients with facial allergic dermatitis who received treatment in Department of Dermatology,Yan’an Hospital of Traditional Chinese Medicine from June 2020 to June 2022 were selected as the study objects.They were divided into a control group(traditional Chinese medicine wet compress)and an observation group(Piyanxiao granule combined with traditional Chinese medicine wet compress)by the random number table method,with 58 patients in each group.The clinical efficacy after 1 month of treatment,the scores of skin color index,skin fever index,and skin itching degree,changes of serum immunoglobulin E(IgE)and eosinophil(EOS)count before and after treatment,and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 74.14%,which was significantly higher than 55.17%in the control group(P<0.05).The scores of skin color index,fever index,and itching degree in the observation group were(0.69±0.12)points,(0.72±0.14)points,and(0.83±0.23)points,which were significantly lower than(1.03±0.23)points,(1.21±0.32)points,and(1.15±0.35)points in the control group(P<0.05).The levels of serum total IgE and EOS count in the observation group were(109.07±16.45)IU/mL and(2.87±0.12)×10^(9)/mL,which were significantly lower than(116.23±16.43)IU/mL and(3.32±0.23)×10^(9)/mL in the control group(P<0.05).The total incidence rate of adverse reactions during treatment in the observation group was 6.90%,which was slightly lower than 8.62%in the control group(P>0.05).Conclusion Piyanxiao granule combined with traditional Chinese medicine wet compress in the treatment of facial allergic dermatitis can not only relieve the symptoms of skin redness,fever and itching,but also improve the body’s inflammation level of patients,with good clinical application effect and few adverse reactions.