柴胡疏肝散加减对缺血性中风后抑郁的预防作用研究

Study on the Preventive Effect of Chaihu Shugansan Addition and Reduction on Depression after Ischemic Stroke

目的评估柴胡疏肝散加减对缺血性中风后抑郁的治疗及预防效果。方法方便选取2020年2月—2022年2月滕州市中医医院住院治疗的86例缺血性中风后抑郁患者设为研究对象。依据统计学软件生成的分组序列均分为参照组与研究组,各选取43例;参照组予常规西医治疗,研究组则予以柴胡疏肝散加减治疗;判别比对两组治疗前后抑郁症状评分、中医症候评分、神经功能缺损评分、日常生活能力评分以及6个月后抑郁复发情况。结果通过治疗,研究组抑郁症状评分(6.18±1.03)分与中医症候评分(3.97±0.82)分均低于参照组的(8.02±1.15)分、(5.85±1.11)分,差异有统计学意义(t=7.815、8.933,P<0.05);NIHSS评分(5.22±1.51)分低于参照组(7.36±2.03)分,差异有统计学意义(t=5.547,P<0.05),Barthel评分(79.78±5.02)分则高于参照组(72.65±4.73)分,差异有统计学意义(t=-6.779,P<0.05);且该组治疗后6个月抑郁总复发率(6.98%)低于参照组(27.91%),差异有统计学意义(χ^(2)=6.541,P<0.05)。结论针对缺血性中风后抑郁运用柴胡疏肝散加减治疗效果优异,其能明显减轻抑郁与中医症候,有助于患者神经功能与日常生活能力的恢复,同时可进一步预防后期复发。

Objective To evaluate the therapeutic and preventive effects of the addition and reduction of Chaihu Shugansan on depression after ischemic stroke.Methods 86 cases of post ischemic stroke depression who were hospitalized in Tengzhou Hospital of Traditional Chinese Medicine from February 2020 to February 2022 were conveniently selected for the study.According to the grouping sequence generated by statistically software,the patients were divided into the reference group and the study group,and 43 cases were selected in each group.The reference group was treated with conventional western medicine,while the study group was treated with Chaihu Shugansan.Before and after the treatment,the two groups were compared in terms of depressive symptom scores,TCM symptom scores,neurological deficit scores,daily life ability scores,and recurrence of depression after 6 months.Results Through treatment,the study group had lower depressive symptom scores(6.18±1.03)points and TCM symptom scores(3.97±0.82)points than(8.02±1.15)points and(5.85±1.11)points in the reference group in a 2-item comparison,and the difference was statistically significant(t=7.815,8.933,P<0.05).The NIHSS scores(5.22±1.51)points was lower than(7.36±2.03)points of the reference group,and the difference was statistically significant(t=5.547,P<0.05),while the Barthel score(79.78±5.02)points was higher than(72.65±4.73)points of the reference group,and the difference was statistically significant(t=-6.779,P<0.05).And the overall recurrence rate of depression 6 months after treatment in study group(6.98%)was lower than that in the reference group(27.91%),and the difference was statistically significant(χ^(2)=6.541,P<0.05).Conclusion The treatment effect of Chaihu Shugansan is excellent for depression after ischemic stroke,which can significantly reduce depression and TCM symptoms,help patients recover their neurological function and daily life ability,and further prevent recurrence in the later stage of the disease.