沙利度胺与奥氮平用于预防高度致吐风险静脉注射抗肿瘤药物所致恶心呕吐的疗效对比

Comparison of the Efficacy of Thalidomide and Olanzapine in Preventing Nausea and Vomiting Caused by Intravenous Antineoplastic Drugs with High Emetogenic Risk

目的对比沙利度胺三联止吐方案及奥氮平三联止吐方案对顺铂或蒽环类联合环磷酰胺化疗所致恶心、呕吐的疗效及安全性。方法方便选取2021年1—12月在南京市高淳人民医院肿瘤科住院抗肿瘤治疗的患者共62例为研究对象,以随机数表法分为两组,奥氮平+托烷司琼+地塞米松(对照组,32例)及沙利度胺+托烷司琼+地塞米松(研究组,30例),比较沙利度胺组与奥氮平组的疗效、安全性及生活质量。结果研究组与对照组预防延迟性呕吐的有效率分别为100.00%、96.88%,不良反应发生率分别为0、3.33%,两组间差异无统计学意义(χ^(2)=0.953、1.084,P>0.05)。治疗前,两组卡式得分比较,差异无统计学意义(P>0.05);治疗后两组卡式得分均降低,且对照组低于研究组,差异有统计学意义(P<0.05)。结论沙利度胺三联止吐方案和奥氮平三联止吐方案对顺铂或蒽环类联合环磷酰胺化疗所致恶心、呕吐均具有较好的临床效果,且均未观察到不良反应增加的风险,两种止吐方案的疗效和安全性相当,可有效改善其生活质量。

Objective To compare the efficacy and safety of thalidomide triple antiemetic regimen and olanzapine triple antiemetic regimen on nausea and vomiting caused by cisplatin or anthracycline combined with cyclophosphamide chemotherapy.Methods A total of 62 patients who were hospitalized for anti-tumor treatment in the Oncology Department of Nanjing Gaochun People's Hospital from January to December 2021 were conveniently selected as the study objects and divided into two groups using random number table method,olanzapine+tropisetron+dexamethasone(control group,32 cases)and thalidomide+tropisetron+dexamethasone(study group,30 cases).Compared the efficacy,safety and quality of life between the thalidomide group and olanzapine group.Results The effective rate of preventing delayed vomiting between the study group and the control group were 100.00%and 96.88%,and the incidence of adverse reactions were 0 and 3.33%,the difference was not statistically significant(χ^(2)=0.953,1.084,P>0.05).Before treatment,there was no statistically significant difference in Karnofsky scores between the two groups(P>0.05).After treatment,the karnofskg score of the two groups were all reduced,and the control group was lower than the study group,and the difference was statistically significant(P<0.05).Conclusion The thalidomide triple antiemetic regimen and the olanzapine triple antiemetic regimen have good clinical effects on nausea and vomiting caused by cisplatin or anthracycline combined with cyclophosphamide chemotherapy.No increased risk of adverse reactions was observed.The two antiemetic regimens are equally effective and safe,can effectively improve their quality of life.