腹腔镜手术联合奥美拉唑三联治疗胃十二指肠溃疡穿孔的疗效分析

Efficacy Analysis of Laparoscopic Surgery Combined with Omeprazole Triple Therapy for Perforated Gastroduodenal Ulcer

目的探究对于胃十二指肠溃疡穿孔患者实施腹腔镜手术联合奥美拉唑三联治疗的作用效果。方法方便选取2019年1月—2023年3月龙口市人民医院收治的56例胃十二指肠溃疡穿孔患者为研究对象,采用随机数表法分成两组,每组28例。参照组采用腹腔镜手术治疗,研究组在参照组基础上联合奥美拉唑三联治疗。对比两组患者临床疗效、炎症水平、前列腺素E_(2)(prostaglandin E_(2),PGE_(2))、氨基己糖、康复指标及治疗期间不良反应发生情况。结果研究组临床治疗总有效率为96.43%明显优于参照组的71.43%,差异有统计学意义(χ^(2)=4.766,P<0.05)。研究组肿瘤坏死因子-α(tumor necrosis factor-alpha,TNF-α)、白细胞介素-6(in⁃terleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)及白细胞计数(white blood cell count,WBC)低于参照组,PGE_(2)及氨基己糖高于参照组,开始进食时间、置管时间、幽门螺杆菌转阴时间及住院时间短于参照组,差异有统计学意义(P<0.05)。结论胃十二指肠溃疡穿孔患者采用腹腔镜手术联合奥美拉唑三联治疗取得显著的临床疗效,能有减轻胃肠道炎症反应,促进病情康复。

Objective To investigate the effect of laparoscopic surgery combined with omeprazole triple therapy in patients with perforated gastroduodenal ulcer.Methods 56 patients with gastroduodenal ulcer perforation admitted to Longkou People's Hospital from January 2019 to March 2023 were conveniently selected as the study objects,and were divided into two groups by random number table method,with 28 cases in each group.The reference group was treated with laparoscopic surgery,and the study group was combined with omeprazole triple therapy based on the reference group.The clinical efficacy,inflammation level,prostaglandin E_(2)(PGE_(2)),amino-hexose,rehabilitation indexes and the occurrence of adverse reactions during treatment were compared between the two groups.Results The total effective rate of the study group(96.43%)was significantly better than that of the reference group(71.43%),and the difference was statistically significant(χ^(2)=4.766,P<0.05).Tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),C-reactive protein,CRP and white blood cell count(WBC)in the study group were lower than those in the reference group,PGE_(2)and aminohexose were higher than those in the reference group,and the time to start eating,catheter placement time,helicobacter pylori negative transition time and hospital stay were shorter than those in the reference group,and the difference was statistically significant(P<0.05).Conclusion Patients with perforated gastroduodenal ulcer were treated with laparoscopic surgery combined with omeprazole,which can reduce gastrointestinal inflammation and promote rehabilitation.