N,N-二乙基10-十一烯酰胺的合成及驱蚊效果

Synthesis and repellent efficacy of N,N-diethyl-10-undecylamide against Aedes albopictus(Diptera:Culicidae)

介绍了一种新型烯酰胺驱避剂-N,N-二乙基10-十一烯酰胺的合成路线,所得样品的化学结构通过仪器分析及对白纹伊蚊Aedes albopictus的驱避效果。通过红外光谱、GC/MS质谱、核磁共振进行化合物结构分析,参照GB 15193.3—2014方法进行毒性实验及按照GB/T 13917.9—2009方法进行实验室和现场驱蚊试验。结果表明,仪器分析证实了新化合物的结构是■。N,N-二乙基10-十一烯酰胺的小鼠经口LD_(50)>2000 mg/kg体重,属于低毒。N,N-二乙基10-十一烯酰胺乙醇溶液对白纹伊蚊的有效保护时间(h)随着浓度(%)增加而延长,其10%N,N-二乙基10-十一烯酰胺乙醇溶液的有效保护时间为(6.0±1.3)h。对照药10%避蚊胺(DEET)乙醇溶液的有效保护时间为(5.6±1.5)h。现场应用10%N,N-二乙基10-十一烯酰胺乙醇溶液防止白纹伊蚊叮咬,其有效保护时间为(5.8±0.4)h。5 h的保护率为100%,6 h的保护率为98.86%,7 h的保护率为73.91%。现场应用对照药10%避蚊胺(DEET)乙醇溶液的有效保护时间为(5.2±0.4)h。5 h的保护率为100%,6 h的保护率为87.50%,7 h的保护率为57.61%。N,N-二乙基10-十一烯酰胺驱避剂性质稳定,驱蚊效果好,使用安全,具有良好的应用前景。

A new synthetic route for N,N-diethyl-10-undecylamide was introduced.The chemical structure and Aedes albopictus repellency data on N,N-diethyl-10-undecylamide derived from IR,GC/MS and NMR were modeled by using molecular descriptors calculated by GB 15193.3—2014 and GB 15193.3-2014 method.Thecrystal structure of thee newcompound N,N-diethyl-10-undecylamide■transoral LD50:mouse greater than 2000 mg/kg),was determined by instrumental analysis.The effective Ae.albopictus protection time,of N,N-diethyl-10-undecylamide in ethanol solution,increased with the concentration.At low concentration,i.e.10%,N,N-diethyl-10-undecylamide ethanol solution provided a protection time lasting between(6.0±1.3)h against Ae.albopictus in the laboratory,as compared with 10%DEET(control)ethanol solution(5.6±1.5)h,which was slightly less effective.In order to prevent Ae.albopictus bites under field conditions,10%N,N-diethyl-10-undecylamide ethanol solution provided a protection time lasting between(5.8-7)h.While,the protection rate was 100,98.86,and 73.91%(at 5,6 and 7 h,respectively),as compared with 10%DEET ethanol solution(control)which provided a protection time of(5.2±0.4)h with the protection rate 100,87.50 and 57.61%(at 5,6 and 7 h respectively).Thus,we have found that crystal structure of N,N-diethyl-10-undecylamide has stable properties,mosquito repellent effect,good application prospect and it coulb be regarded as safe when used according to instructions.