21世纪全球视域下的柴胡热点前沿知识图谱构建及可视化分析

Knowledge graph construction and visualization analysis of hotspots and frontiers of Bupleuri Radix in 21st century global perspective

目的通过对近20年柴胡相关研究的文献分析,探析柴胡研究领域的相关热点与前沿。方法以中国知网(CNKI)、万方(Wanfang)、维普(VIP)以及Web of Science(WOS)等国内外数据库为数据源,运用COOC对数据进行处理筛选,运用VOSviewer对文献年度发文量、机构、关键词、作者等内容进行分析,绘制可视化图谱。结果共纳入中文文献64919篇,英文文献200篇。文献数量整体呈增长趋势;研究机构主要以中南大学和北京中医药大学为代表;中、英文关键词显示,柴胡的主要研究方向为柴胡皂苷、柴胡疏肝散、药动学、小柴胡汤等;目前柴胡的研究热点主要为柴胡皂苷、中医药疗效、临床应用以及柴胡的相关方剂等。结论柴胡研究目前处于快速发展阶段,该领域的最新进展主要集中于对其临床疗效、药理作用的靶点、信号通路以及基因层面的深入研究等。

Objective To analyze the relevant hot spots and frontiers in the research field of Chaihu(Bupleuri Radix)through the literature analysis of Bupleuri Radix related research in the past 20 years.Methods Using domestic and foreign databases such as CNKI,Wanfang,VIP and Web of science(WOS)as data sources,COOC was used to process and screen the data,and VOSviewer was saikosaponin,Chaihu Shugan San(柴胡疏肝散),pharmacokinetics,Xiaochaihu Decoction(小柴胡汤),etc.At present,the research focus of Bupleuri Radix mainly included saikosaponin,curative effect of traditional Chinese medicine,clinical application and relevant prescriptions of Bupleuri Radix.Conclusion The research of Bupleuri Radix was currently in a rapid development stage.The latest progress in this field mainly focuses on its clinical efficacy,pharmacological targets,signaling pathways and gene levels.