摘要
Brain vascular dysfunction in Alzheimer s disease(AD) pathogenesis has become increasingly clea r.Accumulating evidence shows that damaged vascular,including large or small vessels and even neurovascular unit,may accelerate the neuropathological process of AD via disrupting brain hypoperfusion,aberrant angiogenesis,and neuroinflammatory response,etc.Thus,vascular dysfunction makes a substantially contribution to the cognitive decline of AD patients.
基金
supported by the Science and Technology Innovation 2030-Major Projects,No.2022ZD021 1 600
the National Natural Science Foundation of China,Nos.82271574 and82071204 (all to CX)。
