补骨脂注射液在白癜风治疗中的应用进展

Progress of Psoralea corylifolia injection in the treatment of vitiligo

白癜风是一种常见的获得性色素脱失皮肤病,严重影响患者的身心健康。随着生活节奏的加快与精神压力的增加,其发病率呈上升趋势。由于发病机制复杂,白癜风治疗仍然是皮肤科难度最大的挑战之一。目前已有多种治疗方法应用于临床,但效果有限。因此,仍需探索新的治疗手段。补骨脂注射液作为一种中成药,能够促进黑色素合成和转运,并能促使表皮和毛囊中尚未完全破坏的黑色素细胞分裂和增殖。因此,基于补骨脂注射液的联合疗法有望为白癜风的治疗提供一种新型安全有效的手段。本文综述补骨脂注射液治疗白癜风的作用机制、使用方法以及不良反应等。

Vitiligo is a common skin disease with acquired depigmentation,seriously impacting patients′physical and mental health.With the acceleration of life rhythm and the increase in psychological stress,the incidence of vitiligo increases.Because of the complicated pathogenesis,the treatment of vitiligo is still one of the most difficult challenges in dermatology.At present,the therapeutic efficacy for vitiligo is limited although various treatment methods are available.Therefore,new therapeutic approaches still need to be explored.Psoralea corylifolia injection,a proprietary Chinese medicine,can stimulate the synthesis and transport of melanin,and promote the division and proliferation of surviving melanocytes in the epidermis and hair follicles.Hence,the Psoralea corylifolia injection-based combination therapy is expected to provide a new safe and effective treatment for vitiligo.In this paper,we review literature on Psoralea corylifolia injection for vitiligo in respect of the mechanisms,usage and adverse reactions.