Role of RIPK1 in the pathogenesis of acute respiratory distresssyndrome

Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary disease typically caused bymicrobial infections, trauma, inhalation of harmful gases, and other factors. It is characterized by an inflammation inthe lungs and increased alveolar permeability, leading to pulmonary edema and consequently, a low oxygen supply orhypoxemia. ARDS is responsible for 1 in 10 admissions to intensive care units, and the mortality rate for patientswith severe ARDS is as high as 46%. Extensive efforts have been devoted to investigating the pathological mechanismsof ARDS to develop new effective clinical strategies. Recent studies have reported that receptor-interacting serine/threonine kinase 1 (RIPK1) is involved in the pathogenesis of ARDS. RIPK1 is a critical mediator of programmed celldeath and inflammation. Growing evidence suggests that RIPK1 plays a role in the pathogenesis of differentinflammatory diseases and serves as a promising pharmaceutical target. This review summarizes and sheds some lighton the recent findings regarding the role of RIPK1 and related molecules in the pathogenesis of ARDS.