摘要
Exosomes are extracellular vesicles with a 30–150 nm diameter originating from endosomes.In recent years,scientists have regarded exosomes as an ideal small molecule carrier for the targeted treatment of Alzheimer’s disease(AD)across the blood-brain barrier due to their nanoscale size and low immunogenicity.A large amount of evidence shows that exosomes are rich in biomarkers,and it has been found that the changes in biomarker content in blood,cerebrospinal fluid,and urine are often associated with the onset of AD patients.In this paper,some recent advances in the use of exosomes in the treatment of AD are reviewed,and various exosome markers and some latest detection methods are summarized to provide some evidence for the detection or treatment of AD by exosomes.
出处
《BIOCELL》
SCIE
2023年第10期2163-2176,共14页
生物细胞（英文）
基金
funded by grants from the National Key Research and Development Program of China(Grant Number 2021YFA1500400)
Science and Technology Department of Jilin Province(Grant Number 20200201386JC)
Science and Technology Department of Jjilin Province(Grant Number 20190701037GH)
Education Department of Jilin Province(Grant Number JJKH20200948K).
