叶酸联合维生素B_(12)辅助治疗高血压患者的疗效及对同型半胱氨酸水平的影响

Efficacy of Folic Acid Combined with Vitamin B_(12) in The Adjuvant Treatment of Hypertensive Patients and The Effect on Homocysteine Levels

目的:探讨叶酸联合维生素B_(12)辅助治疗高血压患者的疗效,以及对血清同型半胱氨酸(HHcy)水平的调控作用。方法:选取在我院2021年8月—2022年8月就诊的50例高血压患者为研究对象,随机分为对照组和观察组各25例,2组患者间性别、年龄、病程长短间均无差异(P>0.05)。对照组给予常规临床治疗,观察组在此基础上增加叶酸及维生素B_(12)辅助治疗,比较干预3个月后2组患者血压变化情况,以及治疗前后血清Hcy水平变化及差异。结果:治疗后,2组患者血压值均较治疗前显著降低(P<0.5),观察组患者收缩压[(84.34±4.93)vs(89.49±4.87)]mmHg及舒张压[(121.59±9.49)vs(135.43±10.48)]mmHg下降程度显著高于对照组,观察组血压降低有效率为92.0%,对照组为68.0%,观察组总有效率显著高于对照组,差异均有统计学意义(P<0.05)。且经叶酸联合维生素B_(12)辅助治疗后,血清Hcy水平下降程度更高(P<0.05)。结论:叶酸联合维生素B_(12)对高血压患者进行辅助治疗,不仅可有效降低收缩压和舒张压,有较好的降压效果,且血清Hcy水平也得到显著降低。

【Objective】To investigate the efficacy of folic acid combined with vitamin B_(12) in the adjuvant treatment of hypertensive patients and the modulation of serum homocysteine(Hcy)levels.【Method】Totally 50 patients with hypertension who were treated in our hospital from August 2021 to August 2022 were selected as study subjects,and randomly divided into 25 cases each in the control group and the observation group,with no differences in gender,age,and duration of disease between the two groups(P>0.05).The control group was given conventional clinical treatment,and the observation group was treated with folic acid and vitamin B_(12) on the basis of this treatment.The changes in blood pressure and the changes in serum Hcy levels before and after treatment were compared between the two groups after 3 months of intervention.【Result】After treatment,the blood pressure values of both groups were significantly lower than before(P<0.5),and the decrease in systolic blood pressure[(84.34±4.93)vs.89.49±4.87]mmHg and diastolic blood pressure[(121.59±9.49)vs.(135.43±10.48)]mmHg was significantly higher in the observation group than in the control group,and the effective rate of blood pressure reduction was 92.0% in the observation group and 68.0% in the control group,the total effective rate of the observation group was significantly higher than that of the control group,and the difference were statistically significant(P<0.05).The decrease in serum Hcy level was higher after adjuvant treatment with folic acid combined with vitamin B_(12).【Conclusion】Folic acid combined with vitamin B_(12) in the adjuvant treatment of hypertensive patients not only can effectively reduce systolic and diastolic blood pressure,which has a better antihypertensive effect,but also the serum Hcy level was significantly reduced.