营养干预对超重肥胖型多囊卵巢综合征患者雄激素及胰岛素抵抗的影响

Effect of Nutritional Intervention on Androgen and Insulin Resistance in Overweight and Obese Patients with Polycystic Ovary Syndrome

目的:探讨营养干预对超重肥胖型多囊卵巢综合征(PCOS)患者体质指数(BMI)、雄激素及胰岛素抵抗的影响。方法:采用随机对照法,选取2021年5月—2022年12月期间在我院就诊的120例超重肥胖型PCOS患者为研究对象,分为实验组和对照组各60例。对照组在采用达英-35联合二甲双胍治疗的基础上给予正常饮食,实验组在临床常规用药基础上给予轻断食饮食方式的营养干预,比较两组患者干预前后BMI、胰岛素抵抗相关指数,包括空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、雄激素相关指数,包括睾酮(T)、性激素结合球蛋白(SHBG)及游离睾指数(FAI)的变化。结果:干预后,两组患者BMI,血清FPG、FINS、HOMA-IR、T、FAI指标均显著降低,而血清SHBG水平显著增高,且实验组患者上述指标改善情况均显著优于对照组,差异有统计学意义(P<0.05)。结论:以轻断食为营养干预方式,联合临床基础治疗,可有效降低超重肥胖型PCOS患者BMI,且胰岛素抵抗及雄激素相关指标均得到有效改善。

【Objective】To investigate the nutritional intervention on Body mass index(BMI),androgen and insulin resistance in overweight and obese patients with polycystic ovary syndrome(PCOS).【Method】Using Randomized Controlled Method,120 patients with overweight obese PCOS who attended our hospital between May 2021 and December 2022 were selected as study subjects and divided into 60 cases each in the experimental group and the control group.In the control group,normal diet was given on the basis of treatment with Daing-35 combined with metformin,while in the observation group,light fasting diet intervention was given on the basis of regular clinical medication,and BMI,insulin resistance-related indices,including fasting blood glucose(FPG),fasting insulins(FINS),and insulin resistance index(HOMA-IR),and androgen-related indices,including Testosterone(T),Sex hormone binding globulin(SHBG)and Free testosterone index(FAI)were compared between the two groups before and after the intervention.【Result】After the intervention,BMI,serum FPG,FINS,HOMA-IR,T and FAI indexes were significantly reduced in both groups,while serum SHBG level was significantly increased,and the improvement of the above indexes was significantly better in the patients in the nutrition intervention group than in the control group,and the difference was statistically significant(P<0.05)【.Conclusion】Light fasting as nutritional intervention,combined with clinical basic treatment,can effectively reduce the BMI,and insulin resistance and make androgen-related indexes are effectively improved.