单采血小板输注对患者PLT、MPV、PDW和PCT参数的影响

Effects of Apheresis Platelet Transfusion on PLT,MPV,PDW and PCT

目的:探讨患者输注单采血小板前后血小板计数(PLT)、血小板比积(PCT)、平均血小板体积(MPV)、血小板分布宽度(PDW)的变化情况,各参数间的相关性及其临床意义。方法:回顾性分析我院38例输注单采血小板的患者,从医院医嘱管理系统中查阅与输注单采血小板时间点最为接近的血常规结果,比较输注前后PLT、PCT、MPV、PDW变化情况,分析各项参数之间的相关性,分析患者身体质量指数分别与血小板输注后增长倍数和增长值之间的相关性。结果:与输注前相比,输注后患者的PLT、PCT显著增高(均P<0.001),而MPV、PDW无显著差异(P>0.05);患者输注单采血小板前后PLT、PCT的差值与输注前PLT、PCT无相关性(r=0.002,r=0.001),而MPV、PDW的差值与输注前MPV、PDW成负相关(r=-0.462,r=-0.610)。患者输注单采血小板前后PLT增长率和PCT增长率成正相关(r=0.819);患者身体质量指数与血小板输注后增长倍数成正相关(r=0.721),而与增长值无相关性(r=0.374)。结论:单采血小板输注可引起血小板参数发生变化,并呈现不同特征。血小板参数特征性变化及其相关性可作为单采血小板输注疗效的评价参考指标。

Objective:To investigate the changes of platelet count(PLT),plateletcrit(PCT),mean platelet volume(MPV) and platelet distribution width(PDW) before and after apheresis platelet transfusion,the correlation between the parameters and their clinical significance.Methods:A total of 38 patients who received apheresis platelet transfusion were selected,their results of blood routine test closest to the time point of apheresis platelet transfusion were consulted from hospital information system and the changes of PLT,PCT,MPV and PDW were compared before and after transfusion.The correlation between above parameters was analyzed.The correlation of body mass index(BMI) with the increased multiple and increased value after platelet infusion was also analyzed.Results:Compared with pre-infusion,PLT and PCT significantly increased(P<0.001,P<0.001) while MPV and PDW showed no significant difference after apheresis platelet transfusion(P>0.05).The difference of PLT and PCT before and after apheresis platelet transfusion had no correlation with PLT and PCT before transfusion(r=0.002,r=0.001),while the difference of MPV and PDW was negatively correlated with MPV and PDW before transfusion(r=-0.462,r=-0.610).The PLT growth rate was positively correlated with PCT growth rate before and after apheresis platelet transfusion(r=0.819).BMI was positively correlated with the increased multiple of PLT after infusion(r=0.721),but not with the increased value of PLT after infusion(r=0.374).Conclusion:Apheresis platelet transfusion can cause platelet parameters change and shows different characteristics.Characteristic changes of platelet parameters and their correlation can be used as reference indices to evaluate the efficacy of apheresis platelet transfusion.