铁代谢在多发性骨髓瘤疾病进程和耐药中的研究进展

Research Progress of Iron Metabolism in Disease Progression and Drug Resistance of Multiple Myeloma——Review

铁代谢参与了包括多发性骨髓瘤(MM)在内的多种恶性肿瘤的发生发展及耐药过程。本文根据近年来铁代谢与MM的相关研究,从铁过载导致MM细胞铁死亡、缺铁在MM细胞氧化呼吸与增殖中的作用、铁死亡与自噬的相互影响在疾病进程中的作用等方面综述了铁代谢与MM疾病进程的关系,并简述了铁代谢相关物质通过诱导氧化还原失衡、巨噬细胞M2极化导致MM细胞对蛋白酶体抑制剂耐药的机制,旨在为调节铁代谢相关药物应用于MM患者的临床治疗提供理论基础。

Iron metabolism is involved in the development and drug resistance of many malignancies,including multiple myeloma(MM).Based on recent studies on iron metabolism and MM,this paper reviews the relationship between iron metabolism and disease process of MM in terms of iron overload leading to ferroptosis in MM cells,the role of iron deficiency in oxidative respiration and proliferation of MM cells,and the interaction between ferroptosis and autophagy in the disease process.The mechanisms by which iron metabolism-related substances lead to MM cells' resistance to proteasome inhibitors(PI) through inducing redox imbalance and M2 macrophage polarization are also briefly described,aiming to provide a theoretical basis for the application of iron metabolism-related drugs to the clinical treatment of MM patients.