宫颈小细胞神经内分泌癌一例并文献复习

Small Cell Neuroendocrine Carcinoma of the Cervix:A Case Report and Literature Review

宫颈小细胞神经内分泌癌(small cell neuroendocrine carcinoma of the cervix,SCNCC)早期易发生淋巴转移,病理表现独特,易复发,预后差。报告1例SCNCCⅢC1r期病例资料,患者因间断性阴道出血伴下腹痛1个月余就诊,结合盆腔磁共振成像、全腹CT及宫腔镜活检结果诊断为SCNCCⅢC1r期,根据2022年美国国立综合癌症网络(National Comprehensive Cancer Network,NCCN)指南,结合该患者病情,给予患者3个周期的卡铂+依托泊苷新辅助化疗,后行腹腔镜下广泛性子宫切除术+双侧卵巢切除术+双侧输卵管切除术+盆腔淋巴结清扫术+腹主动脉旁淋巴结切除术+抗肿瘤药物腹腔灌注治疗(奈达铂冲洗腹腔)+双侧输尿管支架植入术,术后继续化疗3个周期,术后随访13个月未见复发。

Small cell neuroendocrine carcinoma of the cervix(SCNCC)is prone to lymphatic metastasis in the early stage,unique pathological manifestations,easy to recur,and poor prognosis.Data from one case of SCNCC(stageⅢC1r)is reported.The patient presented with intermittent vaginal bleeding with lower abdominal pain for more than 1 month.Combined with the results of pelvic magnetic resonanace imaging(MRI),total abdominal CT and hysteroscopy with endometrial biopsy,it was diagnosed as SCNCC atⅢC1r stage.According to the 2022 National Comprehensive Cancer Network(NCCN)guidelines,the patient was given 3 cycles of neoadjuvant chemotherapy(carboplatin plus etoposide neoadjuvant),followed by laparoscopic extensive hysterectomy plus bilateral oophorectomy plus bilateral salpingectomy plus pelvic lymph node dissection plus abdominal para-aortic lymphadenectomy plus antitumor drug intraperitoneal perfusion therapy(nidaplatin flushing the abdominal cavity)plus bilateral ureteral stent implantation.After surgery,the patient was given 3 cycles of chemotherapy again.No recurrence was seen in 13 months of postoperative follow-up.