跨性别男性的性别确认激素治疗及其安全监测

Safety Monitoring of Gender-Affirming Hormone Therapy in Transgender Men

性别确认激素治疗(gender affirming hormone therapy,GAHT)是跨性别者进行性别转化不可避免且最为主要的方式,治疗安全性需要更多关注。对于跨性别男性,雄激素的使用无疑会影响其生理指标,甚至会导致一些不良反应。每12周1000 mg肌内注射十一酸睾酮,是目前世界各国跨性别男性主流的GAHT方案,安全性、有效性、经济性和方便性综合最佳;跨性别男性的GAHT,应监测其血细胞比容、肝功能、血脂、血压、瘦体质量、体质量指数和骨密度等,避免雄激素过量引起的不良事件。本文综述跨性别男性GAHT及其安全监测,旨在为中国跨性别男性GAHT的安全合理用药提供参考。

Gender-affirming hormone therapy(GAHT)is the inevitable and most important way for transgender people to undergo gender transition,while the safety of hormone therapy needs more attention.For transgender men,the use of androgen(male hormone)will undoubtedly affect their physiological indicators,and even lead to some adverse reactions.For transgender men,intramuscular injection of testosterone undecanoate(TU)1000 mg every 12 weeks is currently the mainstream GAHT program in the world,with the best safety,effectiveness,economy and convenience.The GAHT of transgender men should be monitored for hematocrit,liver function,blood lipids,blood pressure,lean body mass,body mass index,bone mineral density,etc.,to avoid the possible adverse events caused by excess androgen.This paper reviewed the GAHT of transgender men and its safety monitoring,and provided a reference for safe and rational use of GAHT for Chinese transgender men.