咖啡因对母婴结局的影响研究

Research Progress on the Impact of Caff eine on Maternal and Infant Outcomes

咖啡因广泛存在于多种天然食品和饮料中。由于一般人群和妊娠女性对咖啡因的代谢存在较大差异,因此咖啡因对妊娠结局的影响值得关注。尽管摄入少量的咖啡因是否会对妊娠结局产生不良影响还缺乏高质量的循证医学证据,但妊娠女性大量摄入咖啡因与自然流产、胎儿先天性畸形、低体重儿、死产等妊娠不良结局可能具有相关性。考虑到现有的研究数据在质量和一致性方面还存在较大差异,妊娠期咖啡因摄入量对母婴结局的更多影响还有待进一步研究。在得到更确切的证据之前,参考各国指南推荐,建议妊娠女性将咖啡因摄入量限制在200mg/d以内,以降低不良妊娠结局的风险。

Caffeine is widely present in various natural foods and beverages.Due to significant differences in caffeine metabolism between the general population and pregnant women,the impact of caffeine on pregnancy outcomes deserves attention.Although there is still a lack of high-quality evidence-based medical evidence on whether consuming small amounts of caffeine can have ad-verse effects on pregnancy outcomes,high levels of caffeine intake in pregnant women may be associated with adverse pregnancy outcomes such as spontaneous abortion,congenital malformations of the fetus,low birth weight infants,and stillbirth.Considering the significant differences in quality and consistency of existing research data,further research is needed on the impact of caffeine intake during pregnancy on maternal and infant outcomes.Before obtaining more accurate evidence,it is recommended to refer to national guidelines and limit caffeine intake to 200mg/d for pregnant women to reduce the risk of adverse pregnancy outcomes.