基于肠道菌群探讨针刺治疗慢性疼痛的作用机制

Discussion on Mechanism of Acupuncture in Treatment of Chronic Pain Based on Intestinal Flora

针刺可通过介导免疫途径、内分泌途径、肠自主神经系统递质途径治疗慢性疼痛。肠道菌群可通过脑肠轴对免疫途径、内分泌途径、肠自主神经系统递质途径影响慢性疼痛症状,而针灸对不同肠道菌群的丰度具有良好调控作用。慢性疼痛、针刺及肠道菌群三者密切相关,针灸可通过调节肠道菌群治疗慢性疼痛,但目前临床治疗方案中关于针刺单独治疗慢性疼痛的研究较少,疗效机制不明确;同时在选穴、配穴方面仍未统一,故今后应进一步深入以肠道菌群为靶点,明确针刺治疗相关作用通路及机制;明确最佳选穴、配穴方案,为慢性疼痛治疗提供新方向。

Acupuncture can treat chronic pain by mediating immune pathway,endocrine pathway and intestinal autonomic nervous system transmitter.Intestinal flora can affect chronic pain symptoms through immune pathway,endocrine pathway and in-testinal autonomic nervous system transmitter through brain gut axis,and acupuncture has a good regulatory effect on the abun-dance of different intestinal flora.Chronic pain,acupuncture and intestinal flora are closely related.Acupuncture can treat chron-ic pain by regulating intestinal flora.However,at present,there are few studies on acupuncture alone in the treatment of chronic pain,and the therapeutic mechanism is not clear.At the same time,there is still no unity in the selection and allocation of acu-points,so we should further focus on intestinal flora in the future to clarify the pathway and mechanism of acupuncture treatment and clarify the best point selection and matching scheme,so as to provide a new direction for the treatment of chronic pain.