基于“肝与大肠相通”探讨“肠道菌群-TLR4信号通路”在非酒精性脂肪性肝病的发病机制

Exploring Pathogenesis of"Gut Microbiota Tlr4 Signaling Pathway"in Nonalcoholic Fatty Liver Disease Based on"Connection Between Liver and Large Intestine"

近年来,由于肠道菌群在消化系疾病中发挥多种生物学作用而备受关注。肠道微生物与非酒精性脂肪性肝病(NAFLD)密切相关。“肠道菌群-TLR4信号通路”可通过"肠-肝轴"影响NAFLD的发生发展,而中医学“肝与大肠相通”理论与现代医学“肠-肝轴”学说存在相通、相似之处。基于“肠道菌群-TLR4信号通路”“肝与大肠相通”探讨NAFLD的发病,有助于更深入地认识和阐明该病的发病机制,亦可为探索中医药治疗、预防该病提供新的思路和视角。

Objective In recent years,intestinal microflora has attracted attention because of its many biological functions in di-gestive diseases.Gut microbes are closely associated with nonalcoholic faty liver disease(NAFLD)."Intestinal flora TLR4 sig-naling pathway"can affect the development of NAFLD through"gut-liver axis",and the theory of"liver communicates with large intestine"in traditional Chinese medicine has similarities with the theory of"Gut-liver axis"in modern medicine.There-fore,to explore the pathogenesis of NAFLD based on"intestinal flora TLR4 signaling pathway"and"liver communicating with large intestine"will help us understand the pathogenesis of NAFLD more deeply.It also can provide a new idea and perspective for exploring the treatment and prevention of the disease with traditional Chinese medicine.