他克莫司软膏结合中医辨证施食对口腔扁平苔藓的临床疗效观察

Clinical Observation on the Therapeutic Effect of Tacrolimus Ointment Combined with Traditional Chinese Medicine Syndrome Differentiation in Treating Oral Lichen Planus

目的 探讨他克莫司软膏结合中医辨证施食对口腔扁平苔藓的临床疗效观察。方法 选取2022年1—2022年6月在濮阳市第三人民医院口腔科就诊的口腔扁平苔藓56例患者按随机数字表法分为观察组和对照组,每组28例,对照组饭后清洁口腔干燥后给予0.1%他克莫司软膏涂抹,观察组在对照组基础上给予中医辨证施食。比较两组干预4周的效果、VAS、SAS、SDS得分。结果 观察组总有效率为96.43%,明显高于对照组的71.43%(P<0.05);干预后两组VAS评分均较干预前下降,观察组VAS评分显著低于对照组(P<0.01);干预后两组SAS评分、SDS评分均较干预前降低,观察组SAS评分、SDS评分均低于对照组(P<0.05)。结论 在他克莫司软膏治疗的基础上,辅助辨证施食干预,可以提高口腔扁平苔藓患者治疗效果,减轻疼痛,改善不良情绪。

Objective To explore the application effect of tacrolimus ointment combined with TCM syndrome differentiation in oral lichen planus.Methods Fifty-six patients with oral lichen planus treated in the Department of Stomatology of Puyang No.3 Peoples Hospital from January to June,2022 were randomLy divided into the observation group and the control group,with 28 cases in each group.The control group was given 0.1%tacrolimus ointment after cleaning the oral cavity and drying it after meals,while the observation group was given TCM based on syndrome differentiation.The effect,VAS,SAS and SDS scores of the two groups after 4 weeks of intervention were compared.Results The total effective rate of the observation group was 96.43%,which was significantly higher than that of the control group 71.43%(P<0.05).After the intervention,the VAS scores of the two groups decreased compared with those before the intervention,and the VAS scores of the observation group were significantly lower than those of the control group(P<0.O1).After the intervention,the scores of SAS and SDS in the two groups were lower than those before the intervention,and the scores of SAS and SDS in the observation group were lower than those in the control group,with statistical significance(P<0.05).Conclusion Based on the treatment of tacrolimus ointment,supplemented with food intervention based on syndrome dfferentiation can improve the therapeutic effect,relieve pain and im-prove bad mood of patients with oral lichen planus.