慢性危重症研究进展

Advances in chronic critical illness research

慢性危重症(chronic critical illness,CCI)是度过危重症急性期进展至慢性阶段,但仍需要长时间生命支持和医疗救治的一类疾病。尽管对CCI定义描述较一致,但目前CCI尚无统一的诊断标准。持续性炎性反应-免疫抑制-分解代谢综合征(persistent inflammation immunosuppression catabolism syndrome,PICS)是一种持续炎症、免疫紊乱、继发感染及分解代谢的恶性循环状态,与CCI的发生密切相关。目前临床治疗CCI多以营养支持治疗、免疫调节治疗等为主要手段,但效果欠佳。未来尚需更多的研究来进一步阐述CCI的诊断、发病机制及预防治疗措施。

Chronic critical illness(CCI)is a disease that progresses from the acute stage of critical illness to the chronic stage,but still requires long-term life support and medical treatment.Although the definition of CCI is consistent,there is no unified diagnostic criteria for CCI at present.Persistent inflammation immunosuppression catabolism syndrome(PICS)is characterized by persistent inflammation,immune disorder,secondary infection and catabolism,which is closely related to the occurrence of CCI.Traditional treatment,such as nutritional support therapy and immunomodulatory therapy,are mainly used in clinical treatment,but the treatment is not effective.More studies are needed in the future to further elucidate the diagnosis,pathogenesis,prevention and treatment of CCI.