慢性乙型肝炎肝纤维化MRI诊断专家共识(2023年版)

Expert consensus on MRI diagnosis of liver fibrosis in chronic hepatitis B(version 2023)

慢性乙型肝炎是中国常见的肝脏慢性炎症性疾病,常导致肝实质持续损伤,继而发生肝纤维化,最终可导致肝硬化、肝功能衰竭、肝癌等不良结局。肝纤维化早期有效干预可实现肝纤维化的逆转。因此,及时准确评估肝纤维化程度对慢性乙型肝炎患者的治疗及预后评估具有重要的临床意义。MRI在慢性乙型肝炎肝纤维化的早期评估及疗效监测中发挥着至关重要的作用。目前慢性乙型肝炎肝纤维化MRI扫描方案及相关诊断阈值缺乏统一共识,不利于临床的实际评估与运用。该专家共识在充分复习国内外相关文献的基础上,基于循证医学指南及标准制订方法学,形成慢性乙型肝炎肝纤维化MRI扫描技术及诊断推荐意见,以期为临床肝纤维化诊断提供明确的依据。

Chronic hepatitis B is a common chronic inflammatory disease of the liver in China that frequently results in sustained damage to the liver parenchyma,followed by liver fibrosis,and ultimately progresses to unfavorable outcomes such as cirrhosis,liver failure,and liver cancer.Liver fibrosis reversal can be achieved through early and effective intervention.Therefore,timely and accurate assessment of the degree of liver fibrosis is of great clinical significance for the treatment and prognosis assessment of patients with chronic hepatitis B.MRI plays a crucial role in the early assessment and monitoring of the therapeutic efficacy of liver fibrosis in chronic hepatitis B.Currently,there is a lack of uniform consensus on MRI scanning protocols and related diagnostic thresholds for liver fibrosis in chronic hepatitis B,which is not conducive to practical clinical evaluation and application.This expert consensus is based on a full review of relevant domestic and international literature and the formulation of methodologies based on evidence-based medical guidelines and standards to develop recommendations for MRI scanning techniques and the diagnosis of liver fibrosis in chronic hepatitis B,with a view to providing a clear basis for the clinical diagnosis.