富马酸替诺福韦二吡呋酯对血脂影响的研究进展

Research progress on the effect of tenofovir disoproxil fumarate on blood lipid profile

富马酸替诺福韦二吡呋酯(TDF)是一种新型核苷酸类逆转录酶抑制剂,主要用于治疗人类免疫缺陷病毒和乙型肝炎病毒感染。近年来越来越多的研究发现,TDF治疗可以降低艾滋病和慢性乙型肝炎患者的血脂,而血脂又和疾病进展以及心血管事件的发生息息相关。现就TDF对血脂影响的研究进展作一综述,旨在为TDF的合理用药提供依据。

Tenofovir disoproxil fumarate(TDF)is a novel nucleotide reverse transcriptase inhibitor that is mainly used to treat human immunodeficiency virus(HIV)and hepatitis B virus(HBV)infections.In recent years,an increasing number of studies have demonstrated that TDF treatment can reduce blood lipid levels in patients with AIDS and chronic hepatitis B and has a close correlation with the severity of the disease and the occurrence of cardiovascular events.This article reviews the research progress on the effect of TDF on blood lipid profiles,with the aim of providing a basis for rational use of TDF.