骨科钛植入物抗感染表面修饰的研究进展

Advances in surface modification of orthopedic titanium implants for anti-infection

钛及其合金因具有良好的力学性能和生物相容性,已成为骨科应用最广泛的植入物材料之一。植入物相关感染是骨科内植物手术失败的主要原因。植入物表面抗感染修饰在预防感染的领域中多受重视,发展迅速。该文着重对国内外使钛植入物具有抗菌黏附、杀菌活性或抗生物膜活性的单纯抗感染表面修饰研究现状以及在抗感染基础上同时促进骨整合、成骨或具有免疫调节作用的复合功能表面修饰的研究进展进行综述,为构造具有复合功能的骨科植入物材料提供参考。

Titanium and its alloys have become one of the most widely used implant materials in orthopedics because of their excellent mechanical properties and biocompatibility.Implant-associated infection is the main reason of failure of orthopedic implant surgery.The anti-infection modification of implant surface has received more attention in the field of infection prevention and developed rapidly.This article focuses on the current research status of simple antiinfection surface modifications that make titanium implants possess anti-adhesion,bactericidal activity or antibacterial membrane activity,as well as the research progress of composite functional surface modifications that promote bone integration,osteogenesis or immunomodulatory effects on the basis of anti-infection,so as to provide references for the construction of orthopedic implants with composite functions.