连续性肾脏替代治疗在横纹肌溶解致急性肾损伤中的研究进展

Research progress of continuous renal replacement therapy in rhabdomyolysis-induced acute kidney injury

横纹肌溶解致急性肾损伤(rhabdomyolysis-induced acute kidney injury, RIAKI)是重症监护病房的一种严重临床疾病,有着高病死率和低治愈率的特点。连续性肾脏替代治疗(continuous renal replacement therapy, CRRT)是RIAKI的常见治疗方式。目前尚无指南指导CRRT在RIAKI中的应用,针对这一难题,该文对CRRT治疗RIAKI的优势与局限性,以及在治疗时机、治疗模式、治疗剂量与滤过膜的选择方面的新观点与研究进展进行了综述,目的是为RIAKI患者提供CRRT治疗的理论指导。

Rhabdomyolysis-induced acute kidney injury(RIAKI)is a serious clinical disease in intensive care unit,characterized by high mortality and low cure rate.Continuous renal replacement therapy(CRRT)is a common form of treatment for RIAKI.There are currently no guidelines to guide the application of CRRT in RIAKI.To solve this problem,this article reviews the advantages and limitations of CRRT in the treatment of RIAKI,as well as new viewpoints and research progress in the selection of treatment timing,treatment mode,treatment dose and filtration membrane,with the aim of providing theoretical guidance for the treatment of CRRT in RIAKI patients.