非糜烂性胃食管反流病与消化道菌群相关性研究进展

Research progress on the relationship between non-erosive gastroesophageal reflux disease and gastrointestinal flora

非糜烂性胃食管反流病(non-erosive gastroesophageal reflux disease, NERD)指存在典型的胃食管反流症状但缺乏内镜下食管黏膜损害的一种疾病,其确切发病机制目前仍不明确。已有研究表明,NERD的发生发展可能与消化道菌群相关。消化道菌群可通过影响机体免疫、代谢、神经等功能以直接或间接参与NERD的发生发展。为进一步明确NERD与消化道菌群的可能相关性,该文就NERD与消化道菌群相关性的研究进展进行综述,以期为NERD的诊疗提供新思路。

Non-erosive gastroesophageal reflux disease(NERD)refers to a disease that has typical gastroesophageal reflux symptoms but lacks endoscopic esophageal mucosal damage.Its exact pathogenesis remains unclear.Studies have shown that the occurrence and development of NERD may be related to the gastrointestinal flora.The digestive tract flora can directly or indirectly participate in the occurrence and development of NERD by affecting the body’s immune,metabolic,neurological and other functions.In order to further clarify the possible correlation between NERD and gastrointestinal flora,this article reviews the research progress on the correlation between NERD and gastrointestinal flora,with a view to providing new ideas for the diagnosis and treatment of NERD.