摘要
三级淋巴结构(TLS)是出生后在非淋巴组织中形成的免疫细胞有组织的聚集体。TLS不存在于生理条件,而是在包括自身免疫性疾病、慢性感染和癌症等慢性炎症环境下出现。在癌症进展情况下,TLS促进免疫细胞涌入癌症发生部位,因此作为提高患者抗癌免疫力和良好治疗反应的一种手段而引起了学术界的兴趣,但其形成的驱动因素,以及这些结构对肿瘤内免疫反应的贡献仍不完全清楚。笔者综述了TLS的生物学表现并概述了TLS在口腔癌研究的最新进展。
Tertiary lymphoid structures(TLSs)are organized aggregates of immune cells that form postnatally in nonlymphoid tissues.TLSs are not found under physiological conditions but arise in the context of chronic inflammation,such as autoimmune diseases,chronic infection,and cancer.In the setting of cancer development,TLSs facilitate the influx of immune cells into the cancer site and have therefore attracted interest as a means of improving anticancer immunity and favorable treatment response in patients.In spite of their presumed importance,the drivers of TLSs formation in cancer and the contribution of these structures to intratumoral immune response remain incompletely understood.In this article,the biology of TLSs and their recent advances in oral cancer research were reviewed.
作者
李晨曦
谭小容
魏巍
李慕秋
龚忠诚
Li Chenxi;Tan Xiaorong;Wei Wei;Li Muqiu;Gong Zhongcheng(Oncological Department of Oral and Maxillofacial Surgery,the First Affiliated Hospital of Xinjiang Medical University,School/Hospital of Stomatology Xinjiang Medical University,Urumqi 830054,China;Stomatological Research Institute of Xinjiang Uygur Autonomous Region,Urumqi 830054,China;Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration,School of Stomatology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)
出处
《中华口腔医学研究杂志（电子版）》
CAS
2023年第5期315-321,共7页
Chinese Journal of Stomatological Research(Electronic Edition)
基金
国家自然科学基金(82360481)
口腔颌面发育与再生湖北省重点实验室开放课题基金(2022kqhm008)
新疆维吾尔自治区科研创新项目(XJ2023G174)。
关键词
肿瘤微环境
口腔肿瘤
癌
鳞状细胞
免疫治疗
肿瘤免疫
Tumor microenvironment
Mouth neoplasms
Carcinoma,squamous cell
Immunotherapy
Cancer immunology
