微创下置管抽吸液化引流术对脑出血患者神经功能及炎症因子水平的影响

Effects of minimally invasive aspiration and liquefaction drainage on nerve function and levels of inflammatory factors in patients with cerebral hemorrhage

目的探究微创下置管抽吸液化引流术对脑出血患者神经功能及血清高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平的影响。方法选取2018年10月至2020年10月本院收治的80例脑出血患者作为研究对象,随机分为研究组与对照组,每组40例。对照组采用常规保守治疗,研究组在对照组的基础上联合微创下置管抽吸液化引流术治疗,比较两组临床疗效、美国国立卫生研究院卒中量表(NIHSS)评分及血清炎症因子水平。结果研究组治疗总有效率为97.50%,高于对照组的65.00%,差异有统计学意义(P<0.05)。两组NIHSS评分组间、时间、交互比较差异有统计学意义(P<0.05);治疗前,两组NIHSS评分比较差异无统计学意义;治疗后30、60 d,两组治疗后各时间点NIHSS评分均低于前一时间点,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组hs-CRP、TNF-α、IL-6水平比较差异无统计学意义;治疗后,两组hs-CRP、TNF-α、IL-6水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。结论微创下置管抽吸液化引流术治疗脑出血效果显著,可促进患者神经功能恢复,缓解炎症反应,值得临床推广应用。

Objective To explore the effects of minimally invasive aspiration and liquefaction drainage on nerve function and levels of serum hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in patients with cerebral hemorrhage.Methods A total of 80 patients with cerebral hemorrhage admitted to our hospital from October 2018 to October 2020 were selected as the study subjects,and they were randomly divided into the study group and the control group,with 40 cases in each group.The control group was given routine conservative treatment,while study group was additionally treated with minimally invasive aspiration and liquefaction drainage,the clinical curative effect,scores of National Institute of Health stroke scale(NIHSS)and levels of serum inflammatory factors were compared between the two groups.Results The total response rate of treatment in study group was 97.50%,which was higher than 65.00%in the control group,and the difference was statistically significant(P<0.05).There were significant differences in NIHSS scores between the two groups of group,time points and interaction(P<0.05).Before treatment,there was no significant difference in NIHSS score between the two groups;30,60 d after treatment,NIHSS scores were decreased of the two groups,and the observation group was lower than control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in levels of hs-CRP,TNF-αand IL-6 between the two groups;after treatment,levels of hs-CRP,TNF-αand IL-6 were decreased of the two groups,which were lower in observation group than control group,and the observation group was lower than control group,the differences were statistically significant(P<0.05).Conclusion The curative effect of minimally invasive aspiration and liquefaction drainage is significant in patients with cerebral hemorrhage,which can promote the recovery of nerve function and relieve inflammatory response.