青藤碱抗肿瘤作用机制研究现状

Research Status on Anti-tumor Mechanism of Sinomenine

青藤碱是中药青风藤的主要活性成分。近年来,其抗肿瘤作用受到日益关注。通过综述近年来青藤碱抗肿瘤相关实验研究成果,总结青藤碱抗肿瘤作用的机制,如阻滞肿瘤细胞周期、干预细胞程序性死亡、抗肿瘤细胞侵袭及迁移、对肿瘤相关调节性非编码RNA的作用、协同增敏作用、调节肿瘤微环境等。为进一步青藤碱药理作用研究及临床应用提供理论依据。

Sinomenine is the main active ingredient of traditional Chinese medicine Qingfengteng(Sinomenii Caulis).In re-cent years,its anti-tumor effects have attracted increasing attention.It summarized the anti-tumor effects and mechanisms of sinomenine,such as blocking tumor cell cycle,interfere with programmed cell death,anti-tumor cell invasion and migration,the effect on tumor-related regulatory non-coding RNA and synergistic sensitization,so as to provide a theoretical basis for further development of sinomenine pharmacological action and clinical application.