水中磺胺类药物的氧化降解、反应途径及其产物毒性研究进展

RESEARCH PROGRESS ON OXIDATIVE DEGRADATION,REACTION PATHWAYS AND PRODUCT TOXICITY OF SULFONAMIDES IN WATER

磺胺类药物(SAs)是目前最常见的抗菌类抗生素之一,已在污水处理厂出水和自然水环境等检出,对水生动植物、微生物与人体健康产生潜在危害。但是目前水中微量SAs采用常规生物法降解处理效果并不显著。氧化法作为有效去除水体中SAs的方法之一,是水处理的研究热点。针对水中磺胺类抗生素的药效机理和危害,系统综述了水中磺胺类抗生素的氧化降解的研究进展,阐明了不同氧化方法、反应途径与产物毒性之间的内在联系。同时指出了高级氧化方法在加速磺胺类抗生素去除转化方面效果更好,而直接氧化在减少高毒性中间产物累积和减少抗生素抗性基因方面更具有优势。因此,开发高效的氧化方法需要密切关注磺胺类抗生素中间产物的累积和抗生素的耐药性。

Sulfonamides(SAs)are a class of the most frequently used antibiotics.It has been detected in sewage treatment effluent and natural water environments and has potential harm to aquatic animals,plants,microorganisms,and human health.But at present,the degradation effect of SAs in water by conventional biological methods is not significant.As one of the effective methods to remove SAs from water,oxidation is a research hotspot of water treatment.In view of the efficacy mechanism and harm of sulfonamide in water,the research progress in the oxidative degradation of sulfonamide in water was reviewed,and the internal relations between different oxidation methods,reaction pathways,and the toxicity of the products were clarified.It was also pointed out that advanced oxidation methods were more effective in accelerating sulfonamide removal,while direct oxidation was more advantageous in reducing the accumulation of highly toxic intermediates and reducing antibiotic resistance genes.Therefore,the development of more efficient oxidation methods requires close attention to the accumulation of sulfonamide intermediates and antibiotic resistance.