黏膜相关恒定T细胞在血液系统疾病中的研究现状

Research status on mucosal-associateidnvariant T cells in hematological diseases in primary immune thrombocytopenia

黏膜相关恒定T(MAIT)细胞是机体内一组在进化上保守的T细胞亚群,其特征为具有高度保守的T细胞受体(TCR),以及对微生物代谢产物的高度敏感性。MAIT细胞在多种感染性疾病、自身免疫性疾病和恶性肿瘤中发挥不同作用,尤其是在抵抗病原微生物感染中发挥保护机体的重要作用。研究表明,MAIT细胞可能参与血液系统疾病的发生、发展。笔者拟就MAIT细胞的基本特征、功能,以及在血液系统疾病中的研究现状进行阐述,旨在加深相关研究者对MAIT细胞的认识。

Mucosal-associated invariant T(MAIT)cells are an evolutionarily conserved T cells subset in vivo,characterized by a highly conserved T cell receptor(TCR)and high sensitivity to microbial metabolites.MAIT cells play different roles in various infectious diseases,autoimmune diseases and malignancies tumors,especially play an important role in protecting the body against pathogenic microbial infections.Current research suggest that MAIT cells may be involved in the development and progression of hematological diseases.This article intends to elaborate on basic characteristics and functions of MAIT cells,as well as research status of MAIT cells in hematological diseases,in order to deepen understanding of MAIT cells.