慢性活动性EB病毒感染的研究进展

Research progress of chronic active Epstein-Barr virus infection

慢性活动性EB病毒感染(CAEBV)是EB病毒(EBV)感染T细胞或自然杀伤(NK)细胞导致的淋巴增殖性疾病,具有炎症性及肿瘤性双重特点,罕见且病死率高。CAEBV患者的特征包括反复或持续发作传染性单核细胞增多症样症状,外周血EBV-DNA载量升高,临床表现通常为反复发热、淋巴结大、肝脾大、EBV肝炎、肝功能损伤、血小板减少等。笔者拟通过对近年CAEBV的发病机制、临床特征、诊治及患者预后等多方面的研究进展进行综述,旨在提高临床医师对该病的认识,尽量做到早诊断、早治疗,改善患者的生存。

Chronic active Epstein-Barr virus infection(CAEBV)is a lymphoproliferative disease caused by Epstein-Barr virus(EBV)infecting T cells or natural killer(NK)cells.CAEBV has dual characteristics of inflammation and tumor,rare and high mortality.It is characterized by recurrent or persistent infectious mononucleosis-like symptoms and increased EBV-DNA load in peripheral blood.Clinical manifestations are usually recurrent fever,lymph node enlargement,hepatosplenomegaly,EBV hepatitis,liver function injury,thrombocytopenia and so on.This article reviews research progress of pathogenesis,clinical features,diagnosis,treatment and prognosis of CAEBV in recent years,in order to further enhance clinicians′understanding of the disease,try to achieve early diagnosis and early treatment,and improve the survival of patients.