抗抑郁柴胡方剂及柴胡皂苷类研究进展

Progress on the Mechanism of AAnntitdideeppreressssaannt tC Coommponents of Bupleurum Saponins

抑郁症是当今社会一种高发病率、高致残率、高疾病负担的慢性精神类疾病,对患者身体和生活有极大的不良影响。目前以柴胡为主的常见中药方剂,如逍遥散、柴胡桂枝汤、四逆散等大部分已被基础药效研究或临床实验证实对抑郁症疗效确切。其中柴胡皂苷作为柴胡中最主要的活性成分之一,近年来学者们对其进行了大量的抗抑郁作用研究,在目前被分离出的100多个柴胡皂苷中,发现柴胡总皂苷、柴胡皂苷a、柴胡皂苷d、柴胡皂苷b2等抗抑郁作用机制各有异同,关于柴胡皂苷b1、柴胡皂苷c、柴胡皂苷e等是否具有抗抑郁作用的研究较少,对其是否具有抗抑郁作用仍需深入研究。因此梳理总结柴胡抗抑郁方剂及柴胡皂苷类抗抑郁活性成分相关研究,希望为其开发应用于抑郁症的治疗提供科学依据和数据支撑。

Depression is a kind of chronic mental disease with high morbidity,high disability rate and high disease burden in today's society,which has a great adverse impact on the body and life of patients.At present,Chaihu(Bupleuri Radix)related prescriptions,such as Xiaoyao Powder(道遥散),Chaihu Guizhi Decoction(柴胡桂枝汤),Sini Powder(四逆散),etc,have been confirmed by basic efficacy studies or clinical experiments to treat depression.As one of the most important active ingredients in Chaihu(Bupleuri Radix)have been studied on anti-depressive effects in recent years.Among more than 1o0 isolated saikosaponins,it has been found that the anti-depressive mechanisms of total saikosaponin,saikosaponin a,saikosaponins d and saikosaponins b2 have their similarities and differences.There are few studies on the antidepressant effect of saikosaponin bl,saikosaponin c and saikosaponin e,and further studies are needed to determine whether it has an antidepressant effect.Therefore,studies related to Chaihu(Bupleuri Radix)anti-depression prescription and saikosaponin anti-depression active ingredients were summarized in order to provide scientific basis and data support for their application in the treatment of depression.