基于SEER数据库的胃黏膜相关组织淋巴瘤临床特征和预后分析

Clinical features and prognosis of gastric mucosa-associated lymphoma based on SEER database

[目的]基于SEER数据库分析胃黏膜相关淋巴组织(mucosa-associated lymphoid tissue,MALT)淋巴瘤的临床特征和预后影响因素。[方法]纳入SEER数据库1975~2018年间的胃MALT淋巴瘤病例,提取年龄、性别、种族、手术信息、放化疗信息、病理资料、Ann Arbor分期资料、婚姻状态、生存时间、结局状态的数据信息。采用χ^(2)检验、单因素和多因素Cox回归分析探索预后影响因素。[结果]3202例胃MALT淋巴瘤患者纳入研究,研究人群中位生存时间为76个月。χ^(2)检验示年龄、种族、性别、Ann Arbor分期、是否放疗、婚姻状态对结局预后有一定影响,是否手术及化疗与预后无显著关联。进一步Cox回归分析示非黑白种族患者、较晚Ann Arbor分期(Ⅱ、Ⅲ、Ⅳ期)、未化疗及离异/丧偶/未婚/婚姻状态不详是胃MALT淋巴瘤预后的独立危险因素。接受化疗治疗者预后较好(P<0.05)。[结论]种族、Ann Arbor分期、化疗、离异/丧偶未婚/婚姻状态不详等因素与胃MALT淋巴瘤患者的预后独立相关(P<0.05)。早期诊断胃MALT淋巴瘤并给予积极治疗、密切随访对改善预后有一定临床意义。

[Objective]To analyze the clinical features and prognostic factors of gastric mucosa-associated lymphoid tissue(MALT)lymphoma based on SEER database.[Methods]Gastric MALT lymphoma cases from 1975 to 2018 were included in SEER database,and the data information of age,sex,race,surgical information,radio-chemotherapy information,pathological data,Ann Arbor staging information,marital status,survival time,and outcome status were extracted.χ^(2) test,univariate and multivariate Cox regression analysis were used to explore the prognostic factors.[Results]A total of 3202 patients with gastric MALT lymphoma were included in the study,and the median survival time of the study population was 76 months.χ^(2) test showed that age,race,sex,Ann Arbor stage,radiotherapy or not,and marital status had a certain effect on the outcome and prognosis,while surgery or chemotherapy had no significant correlation with prognosis.Further Cox regression analysis showed that patients of other races except black and white races,late Ann Arborstage(stage Ⅱ,Ⅲ,Ⅳ),nochemotherapy and divorced/widowed/unmarried/unknown marital status were independent risk factors for prognosis of GASTRIC MALT lymphoma.Patients receiving chemotherapy had better prognosis(P<0.05).[Conclusion]Factors such as race,Ann Arbor stage,chemotherapy,divorce/widower unmarried/marital status unknown were independently correlated with prognosis of gastric MALT lymphoma patients(P<0.05).Early diagnosis of gastric MALT lymphoma,active treatment and close follow-up have certain clinical significance to improve prognosis.