成人HIV阴性结核性脑膜炎患者预后不良危险因素研究进展

Research progress on risk factors of poor prognosis in adults with HIV-negative tuberculous meningitis

结核性脑膜炎(TBM)是中枢神经系统结核病最常见、最严重的一种类型,具有高致死率、高致残率的特点,引起全球公共卫生的广泛关注。近年来,随着医疗技术水平的快速发展及对TBM的深入研究,许多评估预后的指标不断被提出,精准预测其预后相关危险因素,对指导实践意义重大,如高龄、延迟治疗、英国医学研究委员会(BMRC)分期高、脑梗死、脑积水、癫痫发作等均是TBM预后不良的独立危险因素。为加强对TBM患者的重视程度,降低其神经后遗症,提高TBM患者的生活质量,本文就影响TBM患者预后不良危险因素的研究进展方面进行综述,供临床参考。

Tuberculous meningitis is the most common and serious type of tuberculosis in the central nervous system,characterized by high mortality and high disability rate,which has aroused widespread concern in global public health.In recent years,with the rapid development of medical technology and in-depth research on TBM,many evaluation indicators of prognosis have been proposed,it is of great significance to accurately predict the risk factors related to the prognosis,such as advanced age,delayed treatment,high staging of the modified British Medical Research Council(BMRC),cerebral infarction,hydrocephalus and seizures,which are regarded as independent risk factors for poor prognosis of TBM.In order to pay more attention to TBM patients,reduce their neurological sequelae and improve their quality of life,this paper reviews the research progress of risk factors affecting poor prognosis of TBM patients for clinical reference.