多发性硬化疾病修饰治疗药物的临床应用现状

Clinical application status of disease-modifying therapy drug for multiple sclerosis

多发性硬化(MS)是以中枢神经系统炎性脱髓鞘病变为主要特点的免疫介导性疾病,主要累及青壮年,病情易反复发作或进展。MS治疗包括急性期治疗和缓解期治疗,其中MS缓解期的疾病修饰治疗(DMT)可有效减少疾病复发,延缓残疾进展。本文主要通过文献回顾,对DMT药物的治疗方案、常见DMT药物的使用方法和注意事项、DMT药物转换及停药时机等进行综述。

Multiple sclerosis(MS)is an immune-mediated disease characterized by inflammatory demyelinating lesions of the central nervous system,Which mainly affects young adults and is prone to recurrent attacks or progression.The treat⁃ment of MS includes acute phase treatment and remission phase treatment.During the remission phase of MS,disease-modifying therapy(DMT)can effectively reduce disease recurrence and delay disability progression.This article mainly reviews the thera⁃peutic strategies,common administration methods,and precautions of DMT drugs,as well as an overview of the considerations for switching or discontinuing DMT drugs.