慢性阻塞性肺疾病劳力性呼吸困难的发生机制和评估方法进展

Pathogenesis and assessment of exertional dyspnea in chronic obstructive pulmonary disease

慢性阻塞性肺疾病是常见的呼吸系统疾病,严重影响患者的生活质量,病死率高。劳力性呼吸困难是慢性阻塞性肺疾病患者最常见的症状,发生机制复杂,药物治疗作用有限。本文对相关机制和评估方法进行综述,以期提高临床医生对慢性阻塞性肺疾病患者劳力性呼吸困难发生机制的认识,强调对其进行准确评价的重要性,探索可以有效改善患者呼吸困难程度,乃至延缓或逆转肺功能下降的有效干预措施。

Chronic obstructive pulmonary disease(COPD)is a common respiratory system disease that seriously affects the quality of life and has a high mortality rate.Exertional dyspnea is the most common symptom in COPD patients with complexed pathogenesis and limited therapeutic drug effects.In this paper,we reviewed the relevant mechanisms and assessment,in order to improve understanding of the pathogenesis of exertional dyspnea in COPD,to emphasize the importance of accurate assessment,and to explore effective interventions that can effectively improve the degree of dyspnea and even delay or reverse the decline in lung function.