结核分枝杆菌乙酰转移酶功能研究进展

Research progress on Mycobacterium tuberculosis acetyltransferase

结核分枝杆菌(MTB)蛋白质乙酰化修饰在毒力、耐药、调控代谢以及宿主抗结核免疫应答等方面起着重要作用。MTB乙酰转移酶不仅能够乙酰化修饰MTB自身蛋白质,而且能够调控宿主蛋白质乙酰化修饰,进而影响结核病的发生发展和转归。深入阐明MTB乙酰转移酶及其靶向调控蛋白质乙酰化修饰,将有助于揭示MTB的致病机制和耐药机制,进而开发新型抗结核药物。本文将系统性综述MTB乙酰转移酶相关功能研究进展,为进一步研究其介导的蛋白质乙酰化修饰,进而开发新的抗结核药物和阐明耐药机制提供理论基础。

The protein acetylation of Mycobacterium tuberculosis(MTB)plays an important role in virulence,drug resistance,regulation of metabolism and host anti-tuberculosis immune response.The proteins acetylation of MTB and host protein could be induced by the MTB acetyltransferase,which is related to the occurrence,development and prognosis of tuberculosis(TB).A clear understanding of the function of MTB acetyltransferase and identification of its targeted regulatory protein acetylation modification is critical to elucidate the pathogenic mechanism and drug resistance mechanism of TB,and then this could then provide new targets for the development of anti-tuberculosis drugs.This article systematically reviewed the research progress on MTB acetyltransferase related functions,which will provide a theoretical basis for further research on its mediated protein acetylation modification,further development of new anti-tuberculosis drugs and elucidation of drug resistance mechanism.