芪斛楂颗粒联合常规西药治疗儿童厌食合并反复呼吸道感染的疗效

Effect of Qihuhaw Granule combined with Conventional Western Medicine on Anorexia combined with Recurrent Respiratory Tract Infection in Children

目的探讨芪斛楂颗粒联合常规西药治疗儿童厌食合并反复呼吸道感染的疗效。方法选取2021年8月至2022年9月于沈阳市儿童医院治疗的100例厌食合并反复呼吸道感染患儿作为研究对象,按照随机数字表法分为观察组(n=50,接受芪斛楂颗粒联合常规西药治疗)与对照组(n=50,接受常规西药治疗)。比较两组患儿治疗效果、症状体征消失时间,治疗前后血清胃泌素(GAS)及胃动素(MOT)水平、T细胞亚群(CD3^(+)和CD4^(+))水平。结果观察组患儿治疗有效率为96.00%,对照组患儿治疗有效率为84.00%,观察组患儿治疗有效率高于对照组,差异有统计学意义(P<0.05);观察组患儿退热时间、咳痰消失时间、喘息消失时间以及肺部湿啰音消失时间短于对照组,差异有统计学意义(P<0.05);治疗前两组患儿GAS及MOT水平比较,差异无统计学意义(P>0.05),治疗后两组患儿GAS及MOT水平升高,且观察组GAS及MOT水平高于对照组,差异有统计学意义(P<0.05);治疗前两组患儿CD3^(+)和CD4^(+)水平比较,差异无统计学意义(P>0.05),治疗后两组患儿CD3^(+)和CD4^(+)水平升高,且观察组CD3^(+)和CD4^(+)水平高于对照组,差异有统计学意义(P<0.05)。结论对厌食合并反复呼吸道感染采用芪斛楂颗粒联合常规西药治疗具有较好的疗效,能加快患儿症状体征缓解,同时还有助于调节免疫功能及厌食状态。

Objective To explore the curative effect of Qihuhaw granules combined with conventional western medicine in the treatment of anorexia combined with recurrent respiratory tract infection in children.Methods A total of 100 children with anorexia complicated with recurrent respiratory tract infection treated in Shenyang Children's Hospital from August 2021 to September 2022 were selected as the study objects,and were divided into observation group(n=50,receiving Qidrobizha granules combined with conventional western medicine)and control group(n=50,receiving conventional western medicine)according to random number table method.The therapeutic effect,disappearance time of symptoms and signs,serum gastrin(GAS),motilin(MOT)levels and T cell subsets(CD3^(+)and CD4^(+))levels before and after treatment were compared between the two groups.Results The treatment effective rate was 96.00%in the observation group and 84.00%in the control group.The treatment effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The time of fever reduction,sputum disappearance,wheezing disappearance and lung moist rales disappearance in observation group were shorter than those in control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in GAS and MOT levels between the two groups(P>0.05).After treatment,GAS and MOT levels increased between the two groups,and GAS and MOT levels in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the levels of CD3^(+)and CD4^(+)between the two groups(P>0.05).After treatment,the levels of CD3^(+)and CD4^(+)between the two groups increased,and the levels of CD3^(+)and CD4^(+)in the observation group were higher than those in the control group(P<0.05).Conclusion Qidrobizha granule combined with conventional western medicine has a good effect on the treatment of anorexia complicated with recurrent respiratory tract infection,which can accelerate the relief of symptoms and signs,and also help to regulate the immune function and anorexia state.