巴豆煅丝瓜络合重用黄芪、白术治疗肝病顽固性腹水的临床效果研究

Study on the clinical effect of Badou Duan Sigualuo combined with high-dosage astragalus membranaceus and atractylodes macrocephala in the treatment of refractory ascites in liver disease

目的探讨巴豆煅丝瓜络合重用黄芪、白术治疗肝病顽固性腹水的临床效果。方法42例肝病顽固性腹水患者,随机分为研究组及对照组,每组21例。对照组进行常规的肝病腹水治疗,研究组在对照组基础上联合中药巴豆煅丝瓜络合重用黄芪、白术治疗。比较两组患者治疗效果以及治疗前后的中医证候评分、体重、肝脏功能Child-Pugh分级评分。结果研究组的治疗总有效率90.48%高于对照组的61.90%,差异具有统计学意义(P<0.05)。治疗后,两组患者中医证候评分均低于治疗前,且研究组中医证候评分(16.08±3.14)分低于对照组的(21.07±6.05)分,差异具有统计学意义(P<0.05)。治疗后,研究组患者体重(52.02±5.96)kg低于治疗前的(57.21±6.97)kg及对照组的(55.98±5.34)kg,差异具有统计学意义(P<0.05)。治疗后,研究组患者肝脏功能Child-Pugh分级评分(5.31±2.83)分低于治疗前的(8.72±3.43)分及对照组的(7.39±2.91)分,差异具有统计学意义(P<0.05)。结论巴豆煅丝瓜络合重用黄芪、白术治疗肝病顽固性腹水有显著的效果,有一定的临床价值。

Objective To discuss the clinical effect of Badou Duan Sigualuo combined with highdosage astragalus membranaceus and atractylodes macrocephala in the treatment of refractory ascites in liver disease.Methods A total of 42 patients with refractory ascites in liver disease were randomly divided into study group and control group,with 21 cases in each group.The control group was treated with conventional treatment,and the study group was treated with Badou Duan Sigualuo,high-dosage astragalus membranaceus and atractylodes macrocephala on the basis of the control group.The therapeutic effect and the traditional Chinese medicine syndrome score,body weight,Child-Pugh grading score of liver function before and after treatment were compared between the two groups.Results The total effective rate of 90.48%in the study group was higher than that of 61.90%in the control group,and the difference was statistically significant(P<0.05).After treatment,the traditional Chinese medicine syndrome score of the two groups was lower than that of this group before treatment,and the traditional Chinese medicine syndrome score of(16.08±3.14)points of the study group was lower than that of(21.07±6.05)points of the control group.The differences were statistically significant(P<0.05).After treatment,the body weight of(52.02±5.96)kg in the study group was lower than that of(57.21±6.97)kg before treatment and that of(55.98±5.34)kg in the control group,and the difference were statistically significant(P<0.05).After treatment,the Child-Pugh grading score of liver function in the study group was(5.31±2.83)points,which was lower than that of(8.72±3.43)points before treatment and that of(7.39±2.91)points in the control group,and the differences were statistically significant(P<0.05).Conclusion Badou Duan Sigualuo combined with high-dosage astragalus membranaceus and atractylodes macrocephala has a significant effect on the treatment refractory ascites in liver disease,and has certain clinical value.