利那洛肽联合小剂量聚乙二醇对克罗恩病肠道准备影响的初步探索

目的探究利那洛肽联合小剂量聚乙二醇方案在克罗恩病(CD)肠道准备中的应用价值。方法纳入2021年2月至2022年2月本院炎症性肠病中心的CD患者为观察对象,根据随机化表分为两组,观察组服用1粒利那洛肽(290μg)+1.5 L聚乙二醇溶液方案,对照组服用3 L聚乙二醇溶液方案,主要对比两组肠道准备方案的肠道波士顿(BBPS)评分、不良反应及耐受性。结果190例CD患者入组,观察组94例,对照组96例。观察组的右半结肠BBPS评分、横结肠BBPS评分、总结肠BBPS评分高于对照组(P<0.05)。同时不良反应均低于对照组(P>0.05)。肠道狭窄亚群中观察组肠道清洁合格率(BBPS≥6分)高于对照组(P<0.05),且不良反应低于对照组(P<0.05)。结论针对CD这类特殊人群,利那洛肽联合小剂量聚乙二醇优化方案能有效提高肠道准备质量,减少不良反应,有较好的应用价值。

Objective To investigate the value of linaclotide combined with a low-dose polyethylene glycol regimen in bowel preparation for Crohn's disease(CD).Methods Patients with Crohn's disease(CD)in the Center of Inflammatory Bowel Disease of our Hospital from February 2021 to February 2022 were enrolled as subjects.According to the randomization table,the patients were divided into two groups,the experimental group received 1 linaclotide(290μg)+1.5 L polyethylene glycol solution.The control group was given 3L polyethylene glycol solution,and the intestinal Boston(BBPS)score,adverse reactions and tolerability were mainly compared between the two groups under different intestinal preparation schemes.Results 190 CD patients were enrolled,94 in the observation group and 96 in the control group.The right hemicolon BBPS score,transverse colon BBPS score,and summary bowel BBPS score of the observation group were higher than those of the control group(P<0.05).Meanwhile,the adverse reactions were lower than those in the control group(P>0.05).In the intestinal stenosis subgroup,the observation group had a higher intestinal cleansing pass rate(BBPS≥6 points)than the control group(P<0.05),and the adverse reactions were lower than those in the control group(P<0.05).Conclusion For Crohn's disease,linaclotide combined with low-dose polyethylene glycol can effectively improve the quality of intestinal preparation and reduce the occurrence of adverse reactions,which has good application value.