纳洛酮联合醒脑静在COPD合并Ⅱ型呼吸衰竭中的疗效及对预后的影响

Naloxone Combined with Xingnaojing in COPD with TypeⅡRespiratory Failure and its Effect on Prognosis

目的研究纳洛酮联合醒脑静在COPD合并Ⅱ型呼吸衰竭中的疗效及对预后的影响。方法选取2021年1月-2022年6月我院诊治的100例COPD合并Ⅱ型呼吸衰竭患者为研究对象,采用随机数字表法分为对照组和观察组,各50例。对照组采用醒脑静治疗,观察组在对照组基础上给予纳洛酮治疗,比较两组临床疗效、心率和呼吸频率、动脉血气指标[血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]、肺功能指标[一秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、一秒率(FEV_(1)/FVC)]、不良反应发生率。结果观察组治疗总有效率为96.00%,高于对照组的82.00%(P<0.05);观察组治疗后心率、呼吸频率小于对照组(P<0.05);观察组治疗后PaO_(2)高于对照组,PaCO_(2)低于对照组(P<0.05);观察组治疗后FEV_(1)、FVC、FEV_(1)/FVC高于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论纳洛酮联合醒脑静在COPD合并Ⅱ型呼吸衰竭中的效果良好,可有效缓解呼吸衰竭症状显,改善改善肺功能、血气指标,且不增加不良反应发生几率。

Objective To study the effect of naloxone combined with Xingnaojing on COPD complicated with typeⅡrespiratory failure and its effect on prognosis.Methods A total of 100 patients with COPD complicated with typeⅡrespiratory failure diagnosed and treated in our hospital from January 2021 to June 2022 were selected as the research objects.They were divided into control group and observation group by random number table method,with 50 cases in each group.The control group was treated with Xingnaojing,and the observation group was treated with naloxone on the basis of the control group.The clinical efficacy,heart rate and respiratory rate,arterial blood gas indexes[blood oxygen partial pressure(PaO_(2)),arterial blood carbon dioxide partial pressure(PaCO_(2))],lung function indexes[forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC),one second rate(FEV_(1)/FVC)]and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.00%,which was higher than 82.00%in the control group(P<0.05).The heart rate and respiratory rate of the observation group were lower than those of the control group after treatment(P<0.05).PaO_(2)in the observation group was higher than that in the control group,and PaCO_(2)was lower than that in the control group after treatment(P<0.05).FEV_(1),FVC and FEV_(1)/FVC in the observation group were higher than those in the control group after treatment(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Naloxone combined with Xingnaojing has a good effect in COPD complicated with typeⅡrespiratory failure,which can effectively alleviate the symptoms of respiratory failure,improve lung function and blood gas indexes,and does not increase the incidence of adverse reactions.