涎液化糖链抗原6对判定新型冠状病毒感染严重程度的荟萃分析

A meta-analysis of Krebs von den Lungen-6 to determine the severity of COVID-19

目的:涎液化糖链抗原6(krebs von den lungen-6,KL-6)是一种主要由II型肺泡上皮细胞和分泌的糖蛋白,血液中KL-6水平与新冠病毒感染患者严重程度似乎存在相关性.因此,我们进行了荟萃分析,旨在评估血清KL-6水平在判定新冠病毒感染患者严重程度中的作用.方法:在PubMed、the Cochrane Library、中国知网(CNKI)、万方医学数据库检索2019年12月—2022年12月的相关文献.共纳入9项研究,随后使用RevMan 5.4及Stata 17.0进行汇总整合及分析.结果:9项研究中重症患者的血清KL-6显著高于轻中症患者(SMD=1.14,95%CI:0.79~1.49).4项研究中计算的综合诊断参数为:灵敏度0.63(95%CI:0.51~0.75);特异度0.88(95%CI:0.84~0.91);阳性似然比为5.23(95%CI:3.99~6.85);阴性似然比0.42(95%CI:0.30~0.57);受试者工作特征曲线下面积:0.87.结论:在新冠病毒感染病程较重的患者中,KL-6水平显著升高,这表明KL-6可能是识别严重新冠病毒感染患者风险的有效检测指标.

Objective Krebs von den Lungen-6(KL-6)is a glycoprotein mainly secreted by type II alveolar epithelial cells.Blood levels of KL-6 appear to be correlated with the severity of COVID-19 patients.Therefore,we conducted a meta-analysis in this paper to assess the role of serum KL-6 levels in determining the severity of COVID-19 patients.Methods The relevant literatures from December 2019 to December 2022 were searched in PUBMED,the Cochrane Library,CNKI and Wanfang Medical database.A total of 9 studies were included and pooled in the meta-analysis.Use RevMan 5.4 and Stata 17.0 for summary,integration and analysis.Results Serum KL-6 in severe patients was significantly higher than that in mild patients in 9 studies(SMD=1.14,95%CI:0.79-1.49).The composite diagnostic parameters calculated in the four studies were sensitivity 0.63(95%CI:0.51-0.75),specificity 0.88(95%CI:0.84-0.91),positive likelihood ratio 5.23(95%CI:3.99-6.85),negative likelihood ratio 0.42(95%CI:0.30-0.57),and area under the receiver operating characteristic curve 0.87.Conclusion KL-6 levels were significantly elevated in patients with a more advanced course of COVID-19,suggesting that KL-6 may be an effective test for identifying risk in patients with severe COVID-19.