鲁拉西酮对首发精神分裂症患者认知、记忆功能的影响研究

A Study on the Effects of Lurasidone on Cognitive and Memory Functions in Patients with First Episode Schizophrenia

目的研究鲁拉西酮对首发精神分裂症(SCH)患者认知、记忆功能的影响。方法按随机数字表法将2022年1~6月于某院治疗的120例SCH患者分为4组,各30例。A组采用奥氮平治疗,B组采用利培酮治疗,C组采用阿立哌唑治疗,D组采用鲁拉西酮治疗,4组均治疗6个月。比较4组的病情严重程度、认知功能、记忆功能及不良反应。结果4组治疗前的阳性与阴性症状量表(PANSS)评分、认知功能成套测验(MCCB)评分及韦氏记忆量表(WMS-RC)评分比较,差异无统计学意义(P>0.05);4组治疗后的PANSS评分均低于治疗前,MCCB评分及WMS-RC评分均高于治疗前,且D组的PANSS评分均低于A组、B组、C组,MCCB评分及WMS-RC评分均高于A组、B组、C组,差异有统计学意义(P<0.05);D组的TESS评分均低于A组、B组、C组,差异有统计学意义(P<0.05)。结论首发SCH患者采用鲁拉西酮治疗有利于改善患者的阳性、阴性症状及认知、记忆功能,且不良反应少,临床应用安全有效。

OBJECTIVE To investigate the effect of lurasidone on cognitive and memory function in first-episode schizophrenia(SCH)patients.METHODS 120 patients with SCH in a hospital from January to June 2022 who were divided into four groups by random number table method,with 30 patients in each group.Group A was received olanzapine treatment,group B was received risperidone treatment,group C was received aripiprazole treatment,group D was received lurasidone treatment,and all four groups were treated for 6 months.The severity of the condition,cognitive function,memory function,and adverse reactions among the four groups werecompared.RESULTS The results showed that there was no statistically significant difference in the positive and negative symptom scale(PANSS)scores,cognitive function test(MCCB)scores,and Wechsler memory scale(WMS-RC)scores among the four groups before treatment(P>0.05).After treatment,the PANSS scores of all four groups were lower than that of before treatment,while the MCCB and WMS-RC scores were higher than that of before treatment.Moreover,the PANSS scores of group D were lower than those of group A,group B,and group C.The MCCB and WMS-RC scores were higher than those of group A,group B,and group C,and the difference was statistically significant(P<0.05).The TESS scores of group D were lower than those of group A,group B,and group C,with statistically significant differences(P<0.05).CONCLUSION The treatment of first-episode SCH patients with lurasidone is beneficial for improving their positive and negative symptoms,cognitive and memory functions,with less adverse reactions.Its clinical application is safe and effective.